Set in Manhattan in 1995, LANDLINE follows three women in one family having lots of sex, drugs, and Japanese food. Navigating monogamy, honesty, and a long-lost New York, the Jacobs family lives in the last days when people still didn't have cell phones and still did smoke inside. Teenage Ali discovers her dad's affair, her older sister Dana uncovers her own wild side, and their mother Pat grapples with the truth that she can't have it all, but her family still has each other. For a generation raised on divorce and wall-to-wall carpeting, LANDLINE is an honest comedy about what happens when sisters become friends and parents become humans.

After nearly four decades together, Ben (John Lithgow) and George (Alfred Molina) finally tie the knot in an idyllic wedding ceremony in lower Manhattan. But when George loses his job soon after, the couple must sell their apartment and - victims of the relentless New York City real estate market - temporarily live apart until they can find an affordable new home. While George moves in with two cops (Cheyenne Jackson and Manny Perez) who live down stairs, Ben lands in Brooklyn with his nephew (Darren Burrows), his wife (Marisa Tomei), and their temperamental teenage son (Charlie Tahan), with whom Ben shares a bunk bed. While struggling with the pain of separation, Ben and George are further challenged by the intergenerational tensions and capricious family dynamics of their new living arrangements.